연구진흥

창의적인 신지식 창출과 산업계와의 협력적 네트워크 구축

HIGHLY CITED PAPERS (HCP)

  • 전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
  • 매월 1회 업데이트
SCIE Article
Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity
Author
Kim, J; Park, C; Kim, KH; Kim, EH; Kim, H; Woo, JK; Seong, JK; Nam, KT; Lee, YC; Cho, SY
Corresponding Author Info
Prof. Cho, Soo Young(의생명과학과 조수영 교수)
Professor
E-mail
이메일sooycho@hanyang.ac.kr
Document Type
Source
NPJ PRECISION ONCOLOGY 2022, 9
Times Cited
15 (2023.03.10)
External Information
http://dx.doi.org/10.1038/s41698-022-00251-1
Abstract
[History]
- 이 화제의 논문은(는) 지난 2년간 출판되었으며, Geosciences 관련 학술 분야의 논문 중 상위 0.1%에 오를 수 있을 만큼 많이 3월/4월 2019에서 인용되었습니다.
- 11월/12월 2022부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 Clinical Medicine 관련 학술 분야에서 상위 1%에 올랐습니다.

[Abstract]
Single-cell transcriptomic profiles analysis has proposed new insights for understanding the behavior of human gastric cancer (GC). GC offers a unique model of intratumoral heterogeneity. However, the specific classes of cells involved in carcinogenetic passage, and the tumor microenvironment of stromal cells was poorly understood. We characterized the heterogeneous cell population of precancerous lesions and gastric cancer at the single-cell resolution by RNA sequencing. We identified 10 gastric cell subtypes and showed the intestinal and diffuse-type cancer were characterized by different cell population. We found that the intestinal and diffuse-type cancer cells have the differential metaplastic cell lineages: intestinal-type cancer cells differentiated along the intestinal metaplasia lineage while diffuse-type cancer cells resemble de novo pathway. We observed an enriched CCND1 mutation in premalignant disease state and discovered cancer-associated fibroblast cells harboring pro-stemness properties. In particular, tumor cells could be categorized into previously proposed molecular subtypes and harbored specific subtype of malignant cell with high &#101xpression level of epithelial-myofibroblast transition which was correlated with poor clinical prognosis. In addition to intratumoral heterogeneity, the analysis revealed different cellular lineages were responsible for potential carcinogenetic pathways. Single-cell transcriptomes analysis of gastric pre-cancerous lesions and cancer may provide insights for understanding GC cell behavior, suggesting potential targets for the diagnosis and treatment of GC.
Web of Science Categories
Oncology
Funding
Language
English
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