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HIGHLY CITED PAPERS (HCP)

  • 전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
  • 매월 1회 업데이트
SCIE Article
Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives
Author
Lee, Sang Yeul; Kim, Chul Young; Nam, Tae-Gyu
Corresponding Author Info
Prof. Nam Tae-Gyu(약학과 남태규 교수)
Professor
E-mail
이메일tnam@hanyang.ac.kr
Document Type
Source
DRUG DESIGN DEVELOPMENT AND THERAPY 2020, 14, 5375-5392
Times Cited
80 (2023.03.10)
External Information
http://dx.doi.org/10.2147/DDDT.S275007
Abstract
[History]
- 9월/10월 2022부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 Pharmacology & Toxicology 관련 학술 분야에서 상위 1%에 올랐습니다.

[Abstract]
Platinum (Pt)-based anticancer drugs such as cisplatin have been used to treat various cancers. However, they have some limitations including poor selectivity and toxicity towards normal cells and increasing chemoresistance. Therefore, there is a need for novel metallo-anticancers, which has not been met for decades. Since the initial introduction of ruthenium (Ru) polypyridyl complex, a number of attempts at structural evolution have been conducted to improve efficacy. Among them, half-sandwich Ru-arene complexes have been the most prominent as an anticancer platform. Such complexes have clearly shown superior anticancer profiles such as increased selectivity toward cancer cells and ameliorating toxicity against normal cells compared to existing Pt-based anticancers. Currently, several Ru complexes are under human clinical trials. For improvement in selectivity and toxicity associated with chemotherapy, Ru complexes as photodynamic therapy (PDT), and photoactivated chemotherapy (PACT), which can selectively activate prodrug moieties in a specific region, have also been investigated. With all these studies on these interesting entities, new metalloanticancer drugs to at least partially replace existing Pt-based anticancers are anticipated. This review covers a brief description of Ru-based anticancer complexes and perspectives.
Web of Science Categories
Pharmacology & Pharmacy
Funding
Language
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